NKX6-1 anticorps (Internal Region)

N° du produit ABIN1737379

Cet anticorps Lapin Polyclonal détecte spécifiquement NKX6-1 dans WB, ICC, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour NKX6-1 anticorps (Internal Region) (ABIN1737379)

Antigène: NKX6-1 (NK6 Homeobox 1 (NKX6-1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NKX6-1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NKX6-1 anticorps

Épitope: AA 50-200, Internal Region

Specificité: Reacts with human and mouse Nkx6

Réactivité croisée (Details): 1.

Purification: Antigen affinity purified

Immunogène: A genomic peptide made to an internal region of the human Nkx6.1 protein (within residues 50-200). [Swiss-Prot P78426]

Isotype: IgG

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- IHC - P : 1/50 to 1/100 - WB: 1:100-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, glycerol 30 % , Sodium azide 0.05 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Date de péremption: 6 months

Détails sur NKX6-1

Antigène: NKX6-1 (NK6 Homeobox 1 (NKX6-1))

Autre désignation: Nkx6.1

Sujet: NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain.Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.

UniProt: P78426

Pathways: Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion